The frequency, intensity, and nature of clinical adverse reactions and laboratory abnormalities were similar to those seen in adults. No clinically meaningful changes in laboratory values were observed.
Study on the leaf juice of C roseus showed a dose-dependent lowering of blood glucose in both normal and diabetic rabbits comparable to the standard drug, glibenclamide.
Study of C roseus, A indica and A sativum showed significant antidiabetic activity for all three medicinal plants supporting its Ayurvedic use for diabetes. The anti-cancer drugs, vincristine and vinblastine, are derived from the alkaloids of periwinkle. The alkaloid has growth inhibition effects to some human tumors.
Vincristine, another alkaloid, is used for leukemia in children. Vinblastin is sold as Velban; vincristine, as Oncovin. Crude extracts from different parts of C roseus was tested for antibacterial activity. Extracts from the leaves showed significantly higher efficacy.
Study suggests that bioactive compounds of CR can be a potentially exploited as antibacterial agents. Study showed pattern of inhibition depends on extraction procedure, part of plant used, state of plant, solvent used, and microorganism tested.
The ethanolic extract was most active against almost all bacterial organisms tested. Gram positive bacteria were found more sensitive than gram-negative ones.
Study isolated two triterpenes and three alkaloids. Two alkaloids, ajmalicine and serpentine showed very potent inhibitory activity against CYP2D6. Study showed increased wound contraction and tensile strength, increased hydroxyproline content and supports the topical use of CR in wound healing.
The effects of triadmefon, a triazole compound on the antioxidant potentials and root alkaloid ajmalicine content were studies in two varieties of C roseus, rosea and alba. Triadimefon treatment increased the antioxidant potentials and the indole alkaloid ajmalicine more in the rosea variety than the alba variety content.
Results suggest triadimefon may be a useful tool for increasing alkaloid production in medicinal plants. C roseus is known to produce a distinct spectrum of terpenoid indole alkaloids.
Study of non-colored phenolics in C roseus characterized three caffeoylquinic acids and 15 flavonol glycosides. The scavenging ability of different plant matrices was assessed and a concentration-dependent protective effect was observed for seeds and tissues, with petals found to be most active.
C roseus leaves extract made significant changes in each cardiovascular parameter after investigation with hypotensive and hypolipidemic effects in leaves extract treated animals.
Study of leaves extract of Cr showed potent anthelmintic activity in experimental adult earthworm Pheritima posthuma. There was concentration dependent paralysis and decrease in death time.
In the study, the control drug Piperazine citrate showed more potent anthelmintic activity compared to the methanol aqueous, ethanol and ethylacetate extract.
Study of a dichlormethane: Decreased enzymic activities in liver of diabetic animals were significantly improved after extract treatment.
Increased levels of lipid peroxidation indicative of oxidative stress were also normalized by extract treatment.More than 4, ebooks and many book collections, including archive collections of critical historical material, as well as publisher and topical collections.
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Tsitsirika, Catharanthus roseus, pink periwinkle: Philippine Herbal Medicine - An illustrated compilation of Philippine medicinal plants by DrGodofredo Umali Stuart, with botanical information, chemical properties, folkloric uses and research studies.